Piriformis Syndrome is a neuromuscular disorder that is characterized by pain in the buttock region. It is caused by an irritation or compression of the sciatic nerve, which runs from the lower back through the buttocks and down the back of the leg. Symptoms of Piriformis Syndrome can include pain, numbness, tingling, and burning in the buttocks and down the back of the leg. Treatment for the condition usually involves stretching exercises, physical therapy, and medications.